Ethanolic Extract of Black Cumin Seed Reduced Radical Reactive from Dimethylbenzanthracene Compounds

Abstract Dimethylbenzantracene is a compound that radical reactive, genotoxic, and immunotoxic. Black cumin seeds have antioxidative properties. The study aimed to determine the effect of black seed ethanolic extract as an antioxidant by observing secretion activity ROI NO peritoneal macrophages in Sprague Dawley (SD) rats induced DMBA. This controlled experiment used 30 male SD rats. test animals were randomly divided into six groups. Group I was given standard food drink. II Groups III, IV, V EEBCS doses 5, 25, 125 mg orally for seven weeks, respectively. VI Imboost. From week 3 seven, all 10x20 DMBA, 2x per week.At 16, sacrificed isolated cultured macrophage cells. tested. Data on levels tested ANOVA, followed LSD with confidence level 95%. results showed DMBA induction increased decreased NO.EEBCS grew NO. group had lowest levels. concluded at 5 reduced flow but